Dan's Story
Dan Begg received the devastating news in late November 2023: he was diagnosed with Stage IV Non-Small Cell Lung Cancer. The diagnosis came as a shock to Dan and his family. A lifelong non-smoker who prioritized health and fitness, cancer was the last thing anyone expected.
Dan’s cancer was linked to a rare mutation known as EGFR Exon 20 Insertion mutation, which affects less than 5% of Non-Small Cell Lung Cancer patients. Although cancer research has made significant strides in prevention, screening, and treatment, the rarity of the Exon 20 mutations means that research and FDA-approved treatments remain limited. However, Dan was fortunate to access a first-line treatment—Amivantamab in combination with chemotherapy—newly approved by the FDA in early 2024 and currently the only approved first-line targeted therapy for the Exon 20 mutations.
Despite starting this promising treatment, Dan's cancer progressed just a few weeks later. With incredible courage, he joined a first-in-human clinical trial, hoping for another chance. Sadly, the aggressive nature of his mutation cut his journey short, and he passed away just 15 days after his first trial treatment. In the face of this, Dan made a remarkable decision: he chose to donate his body to the National Cancer Institute for research. His wish was to help advance the understanding of Exon 20 mutations in the hope of sparing others from the suffering he endured.
In his honor, the Exon 20 Group, an advocacy organization for patients with this rare mutation, established The Daniel Begg Lung Cancer Molecular Diagnostics Program. This program aids other patients and families who wish to make the same selfless choice of donating their bodies to cancer research. Dan’s courageous act, along with the invaluable insights gained from his tumors, offers hope for future patients grappling with this devastating disease.
More about Dan
Dan Begg left behind a loving family that includes his wife, Josephine; his daughter, Emery; his mother, Margaret; his brother, Steve, and sister-in-law, Whitney; his nephew, Brooks, and nieces, Elynn and Maggie; his many aunts, uncles, cousins, and extended in-laws on his wife’s side. Dan’s life was full of meaningful relationships that he nurtured with unwavering dedication and love.
A graduate of Bishop Ireton High School, Dan went on to further his education at the University of Mary Washington. He built a successful career in Human Resources, where his exceptional interpersonal skills and passion for helping others allowed him to thrive.
Outside of his professional life, Dan was a man of many passions. He was a devoted Arsenal fan, a fitness enthusiast, and someone who loved exploring new breweries with friends. He also enjoyed playing golf, traveling with Josephine, and spending quality time with his family. Dan’s outgoing and friendly nature made him the life of the party, and he had a remarkable ability to make everyone around him feel welcome, appreciated, and loved.
Among the many titles Dan held—favorite uncle ("Duncle") and devoted husband—his most cherished role was being a father. The bond he shared with his daughter, Emery, brought him unparalleled joy. Though his time with her was heartbreakingly short, he embraced fatherhood with all his heart, excelling in every way.
Dan’s legacy is one of love, laughter, and kindness—a legacy that will be forever cherished by those who knew him. In honor of his memory, we are committed to growing his legacy by starting this foundation, ensuring that his life's impact continues to touch others in meaningful ways.
